Pathophysiology Module 5 Mcqs 2022-23 Pathophysiology Module 5 Mcqs 2022-23 Please enter your email: 1. Earliest feature of correction of iron deficiency anemia is: increase in serum ferritin reticulocytosis increase in RBC count increase in serum iron level immediately 2. RBC contains? iron folic acid vitamin C biotin 3. Chronic leukemias are characterized by : . more than 10% of blast cells in the bone marrow immune destruction of leukemic cells in the bone less than 10% of blast cells in the bone marrow heatus leukemicus 4. The components of anticoagulation system are: antithrombin III angiotensin adrenaline antihemophylic globulin 5. Typical signs of neutrophilic leukocytosis are: nuclear shift to the right decreased number of leukocytes in the blood increased number of neutrophils decreased number of neutrophils 6. All cause reticulocytosis, except: thalassemia aplastic anemia sickle cell anemia chronic blood loss 7. Which causes can lead to the death during leukemia? derangements of metabolism anemia pneumonia fever 8. The coagulation disorder with disturbance of the 2nd stage of blood coagulation is: hemorrhagic newborn disease lack of fibrinogen idiopathic thrombocytopenic purpura thrombocytopenia 9. Factors which induce platelet aggregation prostacycline I2 epinephrine NO prostaglandins 10. Procoagulant activity of the endothelium is caused by the production of: prostaglandin I2 NO angiotensin II prostacyclin 11. The nuclear shift to the right is the increase of the: common count of leukocytes percent of the mature neutrophils with hypersegmentation percent of the lymphocytes count of granular leukocytes 12. Reticulocytes are stained with: brilliant cresyl blue sudan black warthin starry hemotoxylin-eosin stain 13. What concerns to hemorrhagic hemostasiopathias disseminated intravascular coagulation – DIC thrombosis angiopathias thrombocytosis 14. What kind of changes occurs in peripheral blood during acute myeloblastic leukemia? elevated peripheral blood myeloblasts count low peripheral blood myeloblasts count the presence of Botkin-Gumbrecht shadows the absence of hiatus leukemicus 15. Granulocytes are formed in spleen bone marrow liver nodi lymphatici 16. What changes occur in peripheral blood at acute lymphoblastic leukemia? small count of lymphoblasts increased count of megaloblasts a lot of lymphoblasts the presence of Botkin-Gumbrecht bodies 17. The main sign of hemorragic hemostasiopathia is: increased coagulability of blood increased bleeding increased thrombocytopoiesis 18. The cause of the coagulation disorders with disturbance of the first phase of blood coagulation is the deficiency of: vitamin K Hageman’s factor fibrinogen plasmin 19. Disturbances of blood coagulation lead to: disease of hemostasis disease of homeostasis metabolism disorder inflammation 20. Thrombogenesis is promoted by all factors, except: damage to the vascular wall hypolipidemia excess of adrenaline 21. Signs of a regenerative shift to the left are all listed, except: increase in the total number of segmented neutrophils presence of myelocytes, metamyelocytes increase of the nuclear index decrease of the nuclear index 22. The main signs of chronic leukemias in hemogram are : low percent of the blasts the presence of hiatus leukemicus high percent of the blast cells the absence of the blasts 23. Chronic lymphoid leukemia is characterized by: increased number of lymphoblasts more than 60% the presence of the toxic granules in myeloid cells lymphocytosis neutrophilic leukocytosis 24. Leukemoid reaction is characterized by: leukopenia leukocytosis amount of blasts more than 30% hiatus leukemicus 25. The factor which converts the prothrombin to thrombin : factor I factor VII factor IХа factor Ха 26. What type of leukocytes increases in viral infection? eosinophils neutrophils monocytes lymphocytes 27. Normal value of color index is: 0.85-1.0 0.5-0.8 0.1-1.0 0.1-0.8 28. Lack of plasmin leads to disorder of: prothrombinogenesis trombinogenesis fibrinogenesis retraction and fibrinolysis 29. The endothelial cells of intact vessels prevent blood coagulation by secretion of: prostacyclin thromboxane factor IX vitamin К 30. Following are seen in polycythemia vera, except: increased erythropoietin erythrocytosis intrinsic abnormality of hematopoietic precursors erythropoietin independent growth of RBC progenitors 31. Extrinsic pathway of clotting factors is measured by? prothrombin time activated partial thromboplastin time bleeding time clotting time 32. Fibrinolytics – are: antithrombin III antihemophylic globulin heparin plasmin 33. The functions of platelets in hemostasis are: angiotrophic antiadhesive anticoagulative bactericidic 34. Compensatory mechanisms of 1 stage of acute post-hemorrhagic anemia include all listed, except: redistribution of blood vasospasm hemodilution tachycardia 35. Chronic myeloid leukemia is characterized by: eosinophilic-basophilic association . hiatus leukemicus more than 30% of the blast cells in the peripheral blood lymphocytosis 36. What is the cause of hemorrhagic syndrome during leukemia? increased release of intrinsic procoagulants infiltration of the vascular wall by leukemic cells severe anemia severe thrombocytopenia 37. Platelet precursor is: plasmacytoblast myeloblast megakaryoblast lymphoblast 38. What leukocytes present in the peripheral blood of healthy people? myeloblasts promyelocytes lymphoblasts lymphocytes 39. Life span of transfused RBC? 30 days 30 days 60 days 120 days 40. The platelet-vascular hemostasis is necessary for: white trombus formation red thrombus formation the postcoagulative changing of the thrombus vasoconstriction 41. Acute leukemia is characterized by: . more than 10% of blast cells in the bone marrow eosinophilic-basophylic assosiation less than 10% of blast cells in the bone marrow eosinophilia 42. What kind of cells in the peripheral blood indicates acute myeloid leukemia? myelocytes immature lymphocytes myeloblasts lymphocytes 43. The sign of agranulocytosis is: count of leukocytes below 5 х 109 / count of leukocytes below 1 х 109 /l absence of agranular leukocytes increasing count of agranular leukocytes 44. Morphologically recognized granulocytic cell is: lymphoblast myeloblast monoblast erythroblast 45. The synthesis of thrombin is blocked by calcium ions collagen von Willebrand factor anticoagulants 46. What changes occur in peripheral blood at chronic lymphoblastic leukemia? small count of lymphoblasts increased count of myeloblasts the absence of Botkin-Gumbrecht bodies increased amount of eosinophiles and basophiles 47. Thrombogenic property of the endothelium is caused by production of: prostacyclin protein C NO angiotensin II 48. Inhibition of erythropoesis leads to: olygocythemic normovolemia olygocythemic hypovolemia polycythemic normovolemia 49. What platelet factor takes part in the prothrombinase synthesis? 3 platelet factor 4 platelet factor actomyosin thromboxane 50. Endoerythrocytic hemolytic anemias are: membranopathy hemoglobinopathy enzymopathy vasculopathy 51. Vitamin B12 deficiency results in: macrocytic anemia iron deficiency anemia anemia of chronic diseases aplastic anemia 52. Administration of cytostatics leads to: neutrophilia monocytosis thrombocytosis agranulocytosis 53. Iron deficiency anemia is seen with all of the following, except: chronic blood loss achlorhydria extensive surgical removal of the proximal small bowel excess of meat in the diet 54. The coagulation disorders are: Henoch-Schonlein purpura idiopathic thrombocytopenic purpura hemophilia scorbut 55. Leukopenia may be a result of : asthma bone marrow aplasia allergic skin diseases tuberculosis 56. Acute myelogenous leukemia is characterized bу: proliferation of megaloblasts more than 30% of the blast cells in the peripheral blood less than 30% of the blast cells in the peripheral blood lymphocytosis 57. The physiologic leukocytosis occurs in : pregnancy hemorrhage fever tumors 58. One of the developmental stages of lymphocyte is: myeloblast lymphoblast promonocyte monoblast 59. We should differentiate leukemoid reaction of neutrophil type with: chronic lymphatic leukemia chronic myeloid leukemia acute myeloblastic leukemia acute lymphoblastic leukemia 60. Increased osmotic fragility is characteristic of: hereditary microspherocytosis sickle cell anemia thalassemia iron deficiency anemia 61. The anticoagulative effect of plasmin is realized through: inhibition of prothrombinase formation inhibition of thrombin formation inhibition of fibrinogenesis activation of fibrinolysis 62. In aleukemic type of leukemias : amount of leukocytes increases in blood more than 10×109/l amount of leukocytes increases in blood more than 100×109/l amount of leukocytes decreases in blood normal count of leukocytes in blood 63. Glucose-6-phosphate dehydrogenase helps in maintaining the integrity of RBC by: controlling reduction stress on RBC controlling oxidative stress on RBC maintaining flexibility of cell membrane component of electron transport chain 64. Mechanisms of leukopenia are : suppression of leukopoiesis decreased margination of leukocytes in the vascular bed decreased extravasation of leukocytes into tissues decreased leukocyte destruction by the spleen 65. Chronic hypoxia leads to: olygocythemic hypovolemia polycythemic hypovolemia polycythemic normovolemia 66. Leukopenia may be a result of : deficit of iron bacterial infection viral infection activation of leukocyte production 67. Antiaggregant for thrombocytes is: thrombin ADP collagen aspirin 68. Eosinophilia is: high level of neutrophils high level of eosinophils high level of monocytes high level of lymphocytes 69. Deficiency of what factor leads to hemophilia B? VIII IX XI X 70. The types of nuclear shift to the right are: myelocytic degenerative monocytic regenertive 71. Extrinsic coagulation pathway of hemostasis includes activation of: factor VII factor VIII factor IX factor XII 72. Factors which induce platelet aggregation? thromboxane A2 urea ATP prostacycline I2 73. DIC may be caused by: prolonged pregnancy fat embolism amniotic fluid embolism minor injuries 74. Type of leukocytes increase in allergic reactions more often : eosinophils neutrophils lymphocytes monocytosis 75. Trombohemorrhagic hemostasiopathias is a kind of pathology with: increased bleeding increased trombocytopoiesis simultaneous thrombosis and bleeding decreased bleeding 76. Leucopenia is not seen in: viral infection pyogenic bacterial infection decreased leukopoiesis 77. Deficiency of what factor leads to hemophilia A? VIII IX XI X 78. The main sign of trombophilic hemostasiopathias is: increased coagulability of blood increased bleeding increased thrombocytopoiesis simultaneous thrombosis and bleeding 79. Which factor can initiate blood coagulation? factor I factor Х factor ХII prothrombin 80. The nuclear shift to the left (regenerative) is: decrease the mature leucocytes from common count of leucocytes increase the count of immature neutrophils increase percent of the lymphocytes decrease the count of granular leukocytes 81. One of the developmental stages of neutrophylic leukocyte is : myeloblast prolymphocyte promonocyte monoblast 82. The major constituent of white thrombus is: fibrin RBC WBC platelets 83. Hematocrit during polycythemic normovolemia is: increased decreased normal 84. Lack of vitamin K leads to: coagulation disorder disseminated intravascular coagulation (DIC) syndrome thrombocytopenia angiopathia 85. The causes of hemorrhagic angiopathias – are: allergy diabetes insipidus hypovitaminosis Р and С thrombocytopenia 86. Deficiency of prothrombin leads to disorder of: prothrombinogenesis thrombinogenesis fibrinogenesis retraction and fibrinolysis 87. Percentage of blasts in acute myeloid leukemia: 8% 15% more than 20% 88. Substances can split the fibrin molecule? plasmin heparin-like molecule antithrombin III protein C 89. Compensatory mechanism of 2 stage of acute post-hemorrhagic anemia is: redistribution of blood vasospasm hemodilution tachycardia 90. All of the following are true regarding hemolytic anemia, except: reticulocytosis raised unconjugated bilirubin hemosiderinuria raised haptoglobin levels 91. Hemosthasiopathias – are the disturbances of : hemostasis system homeostasis red blood cells white blood cells 92. Increased count of eosinophils and basophils can be observed at: chronic lymphoid leukemia chronic myeloid leukemia acute lymphoblastic leukemia acute myeloblastic leukemia 93. The major constituent of red thrombus is: fibrin RBC WBC platelets 94. Hematocrit during simple normovolemia is: increased decreased normal 95. Dehydration leads to: olygocythemic hypovolemia polycythemic hypovolemia olygocythemic normovolemia 96. GLUT present on surface of RBC? GLUT 1 GLUT 2 GLUT 3 GLUT 4 97. The cause of the coagulation disorder with disturbance of the 3ed stage of blood coagulation are: hemorrhagic newborn disease lack of kininogen idiopathic thrombocytopenic purpura lack of fibrinogen 98. Reticulocytosis is not seen in: thalassemia hereditary spherocytosis chronic renal failure sickle cell anemia 99. All are seen in thalassemia major, except: transfusion dependency splenohepatomegaly macrocytic anemia ineffective erythropoiesis 100. activation of blood coagulation depression of blood coagulation thrombolysis formation of clots activation of blood coaglation 101. Acute purulent inflammatory processes lead to : eosinophilia lymphocytosis neutrophilic leukocytosis basophilia 102. Deficiency of fibrinogen leads to disorder of : synthesis of prothrombinase thrombinogenesis fibrinogenesis retraction and fibrinolysis 103. Substances can split the fibrin molecule? plasminogen plasmin antiplasmin prothrombin 104. Physiologic leukocytosis occurs: in administration of glucocorticoids in physical stress in infections 105. Henoch-Schonlein purpura is : coagulation disorder thrombocytopenia angiopathia trombohemorrhagic hemostasiopathias 106. Lack of calcium leads to: increased hemorrage thrombosis disseminated intravascular coagulation (DIC) syndrome excess of thrombus retraction 107. What diseases are often accompanied with monocytosis? tuberculosis helminthic invasion asthma bacterial pneumonia 108. Fibrin-split products stimulate: synthesis of factor III destruction of fibrin activation of factor XII activation of factor XI 109. Signs of degenerative shift to the left are all listed, except: decrease of the total number of segmented neutrophils presence of myelocytes, young neutrophils increase of the nuclear index increase of the number of stab neutrophils 110. The function of the neutrophils is: synthesis of antibodies phagocytosis secretion of histamine secretion of serotonin 111. The count of platelets lead to hemorrhagic syndrome: is less than 150 х 109 /l is less than 320 х 109 /l is less than 50 х 109 /l is less than 400 х 109 /l 112. Hematocrit during oligocythemic normovolemia is: increased decreased normal 113. Components of anticoagulant system are: antithrombin III antihemophylic globulin angiotensin adrenaline 114. Idiopathic thrombocytopenic purpura is example of a : coagulation disorder thrombocytopenia angiopathy thrombophilia 115. What kind of changes occurs in peripheral blood during chronic myeloid leukemia? the absence of hiatus leukemicus the presence of hiatus leukemicus increase of blast count in peripheral blood blasts cells more than 90% 116. Hiatus leukemicus is the absence of: the maturating cells morphologically undifferentiated cells mature cells blast cells 117. Microcytic hypochromic anemia is seen in: hereditary spherocytosis thalassemia major iron deficiency anemia pernicious anemia 118. The causes of thrombocytopenia are: benign tumor radiation acute hemorrhage jaundice 119. Acute leukemia differs from chronic one by: the presence of anemia the absence of hiatus leukemicus the presence of hiatus leukemicus small blast count in peripheral blood 120. Von Willebrand disease is: angiopathia thrombocytopenia coagulation disorder mixed hemorrhagic hemostasiopathias 121. What disease is accompanied with eosinophilia? asthma bacterial pneumonia myocardial infarction HIV-infection 122. What disease can lead to eosinophilia? croupous pneumonia 2. tuberculosis helminthic invasion cardiac infarction 123. Hemophilia is a: coagulation disorder thrombocytopenia angiopathia thrombohemorrhagic 124. Chronic myeloid leukemia is associated with: a high amount of myeloblasts decreased amount of basophiles and eosinophils absent hiatus leukemicus lymphocytosis 125. Compensatory mechanism of 3 stage of acute post-hemorrhagic anemia is redistribution of blood vasospasm hemodilution tachycardia stimulation of erythropoiesis 126. Inducers of platelets aggregation are: aspirin ATP urea thrombin 127. Hodgkin,s lymphoma is caused by: EBV HHV6 CMV HHV8 128. Anticoagulant system is aimed at: depression of blood coagulation thrombolysis formation of clots activation of blood coagulation 129. What is leukemia? sign of viral infection sign of the inflammation tumor of hematopoietic tissue sign of the allergy 130. Which cells present in peripheral blood at chronic myeloid leukemia? myeloblasts monocytes promonocytes lymphoblasts 131. Coagulation disorders are: scorbut Henoch-Schonlein purpura idiopapthic thrombocytopenic purpura hemophilia 132. Nuclear shift shows : type of leukocytosis severity of inflammation type of leukopenia stage of inflammation 133. Index of the nuclear shift is relation: of the count of immature forms of neutrophils to mature ones: of granulocytes and nongranilocytes of the count of granulocytes to band forms of the myeloblasts to myelocytes 134. What are the main changes in the hemogram during acute leukemia? low percent of the blasts the presence of the cells of 5 class of maturation the presence of hiatus leukemicus monocytosis Loading …What is the color of the snow?
