Pathophysiology Module 5 Mcqs 2022-23 Pathophysiology Module 5 Mcqs 2022-23Please enter your email: 1. Deficiency of fibrinogen leads to disorder of : synthesis of prothrombinase thrombinogenesis fibrinogenesis retraction and fibrinolysis 2. Granulocytes are formed in spleen bone marrow liver nodi lymphatici 3. activation of blood coagulation depression of blood coagulation thrombolysis formation of clots activation of blood coaglation4. Substances can split the fibrin molecule? plasminogen plasmin antiplasmin prothrombin5. Reticulocytosis is not seen in: thalassemia hereditary spherocytosis chronic renal failure sickle cell anemia6. Leucopenia is not seen in: viral infection pyogenic bacterial infection decreased leukopoiesis7. Hiatus leukemicus is the absence of: the maturating cells morphologically undifferentiated cells mature cells blast cells8. Factors which induce platelet aggregation prostacycline I2 epinephrine NO prostaglandins9. Extrinsic coagulation pathway of hemostasis includes activation of: factor VII factor VIII factor IX factor XII 10. The functions of platelets in hemostasis are: angiotrophic antiadhesive anticoagulative bactericidic 11. Type of leukocytes increase in allergic reactions more often : eosinophils neutrophils lymphocytes monocytosis12. Trombohemorrhagic hemostasiopathias is a kind of pathology with: increased bleeding increased trombocytopoiesis simultaneous thrombosis and bleeding decreased bleeding13. What platelet factor takes part in the prothrombinase synthesis? 3 platelet factor 4 platelet factor actomyosin thromboxane 14. Lack of plasmin leads to disorder of: prothrombinogenesis trombinogenesis fibrinogenesis retraction and fibrinolysis 15. What kind of changes occurs in peripheral blood during acute myeloblastic leukemia? elevated peripheral blood myeloblasts count low peripheral blood myeloblasts count the presence of Botkin-Gumbrecht shadows the absence of hiatus leukemicus 16. Inhibition of erythropoesis leads to: olygocythemic normovolemia olygocythemic hypovolemia polycythemic normovolemia17. Chronic myeloid leukemia is associated with: a high amount of myeloblasts decreased amount of basophiles and eosinophils absent hiatus leukemicus lymphocytosis18. Physiologic leukocytosis occurs: in administration of glucocorticoids in physical stress in infections19. The major constituent of red thrombus is: fibrin RBC WBC platelets 20. Acute leukemia is characterized by: . more than 10% of blast cells in the bone marrow eosinophilic-basophylic assosiation less than 10% of blast cells in the bone marrow eosinophilia21. Disturbances of blood coagulation lead to: disease of hemostasis disease of homeostasis metabolism disorder inflammation 22. Which cells present in peripheral blood at chronic myeloid leukemia? myeloblasts monocytes promonocytes lymphoblasts 23. Hemophilia is a: coagulation disorder thrombocytopenia angiopathia thrombohemorrhagic 24. We should differentiate leukemoid reaction of neutrophil type with: chronic lymphatic leukemia chronic myeloid leukemia acute myeloblastic leukemia acute lymphoblastic leukemia 25. Following are seen in polycythemia vera, except: increased erythropoietin erythrocytosis intrinsic abnormality of hematopoietic precursors erythropoietin independent growth of RBC progenitors26. Glucose-6-phosphate dehydrogenase helps in maintaining the integrity of RBC by: controlling reduction stress on RBC controlling oxidative stress on RBC maintaining flexibility of cell membrane component of electron transport chain27. Deficiency of what factor leads to hemophilia B? VIII IX XI X28. The main sign of trombophilic hemostasiopathias is: increased coagulability of blood increased bleeding increased thrombocytopoiesis simultaneous thrombosis and bleeding 29. All of the following are true regarding hemolytic anemia, except: reticulocytosis raised unconjugated bilirubin hemosiderinuria raised haptoglobin levels30. Leukopenia may be a result of : asthma bone marrow aplasia allergic skin diseases tuberculosis31. Henoch-Schonlein purpura is : coagulation disorder thrombocytopenia angiopathia trombohemorrhagic hemostasiopathias 32. Compensatory mechanisms of 1 stage of acute post-hemorrhagic anemia include all listed, except: redistribution of blood vasospasm hemodilution tachycardia33. Hematocrit during polycythemic normovolemia is: increased decreased normal34. Hematocrit during oligocythemic normovolemia is: increased decreased normal35. Antiaggregant for thrombocytes is: thrombin ADP collagen aspirin 36. Acute leukemia differs from chronic one by: the presence of anemia the absence of hiatus leukemicus the presence of hiatus leukemicus small blast count in peripheral blood 37. The main signs of chronic leukemias in hemogram are : low percent of the blasts the presence of hiatus leukemicus high percent of the blast cells the absence of the blasts 38. The coagulation disorder with disturbance of the 2nd stage of blood coagulation is: hemorrhagic newborn disease lack of fibrinogen idiopathic thrombocytopenic purpura thrombocytopenia39. What changes occur in peripheral blood at chronic lymphoblastic leukemia? small count of lymphoblasts increased count of myeloblasts the absence of Botkin-Gumbrecht bodies increased amount of eosinophiles and basophiles 40. Thrombogenesis is promoted by all factors, except: damage to the vascular wall hypolipidemia excess of adrenaline41. The sign of agranulocytosis is: count of leukocytes below 5 х 109 / count of leukocytes below 1 х 109 /l absence of agranular leukocytes increasing count of agranular leukocytes 42. Deficiency of what factor leads to hemophilia A? VIII IX XI X43. The nuclear shift to the right is the increase of the: common count of leukocytes percent of the mature neutrophils with hypersegmentation percent of the lymphocytes count of granular leukocytes 44. The causes of thrombocytopenia are: benign tumor radiation acute hemorrhage jaundice 45. The types of nuclear shift to the right are: myelocytic degenerative monocytic regenertive46. Extrinsic pathway of clotting factors is measured by? prothrombin time activated partial thromboplastin time bleeding time clotting time47. What disease is accompanied with eosinophilia? asthma bacterial pneumonia myocardial infarction HIV-infection48. Typical signs of neutrophilic leukocytosis are: nuclear shift to the right decreased number of leukocytes in the blood increased number of neutrophils decreased number of neutrophils49. Von Willebrand disease is: angiopathia thrombocytopenia coagulation disorder mixed hemorrhagic hemostasiopathias 50. Eosinophilia is: high level of neutrophils high level of eosinophils high level of monocytes high level of lymphocytes51. Factors which induce platelet aggregation? thromboxane A2 urea ATP prostacycline I2 52. Hodgkin,s lymphoma is caused by: EBV HHV6 CMV HHV853. All are seen in thalassemia major, except: transfusion dependency splenohepatomegaly macrocytic anemia ineffective erythropoiesis54. Platelet precursor is: plasmacytoblast myeloblast megakaryoblast lymphoblast 55. Life span of transfused RBC? 30 days 30 days 60 days 120 days56. Which causes can lead to the death during leukemia? derangements of metabolism anemia pneumonia fever57. Procoagulant activity of the endothelium is caused by the production of: prostaglandin I2 NO angiotensin II prostacyclin58. All cause reticulocytosis, except: thalassemia aplastic anemia sickle cell anemia chronic blood loss59. Administration of cytostatics leads to: neutrophilia monocytosis thrombocytosis agranulocytosis 60. The physiologic leukocytosis occurs in : pregnancy hemorrhage fever tumors61. Acute myelogenous leukemia is characterized bу: proliferation of megaloblasts more than 30% of the blast cells in the peripheral blood less than 30% of the blast cells in the peripheral blood lymphocytosis62. The function of the neutrophils is: synthesis of antibodies phagocytosis secretion of histamine secretion of serotonin 63. Deficiency of prothrombin leads to disorder of: prothrombinogenesis thrombinogenesis fibrinogenesis retraction and fibrinolysis 64. Hematocrit during simple normovolemia is: increased decreased normal65. Fibrin-split products stimulate: synthesis of factor III destruction of fibrin activation of factor XII activation of factor XI66. The anticoagulative effect of plasmin is realized through: inhibition of prothrombinase formation inhibition of thrombin formation inhibition of fibrinogenesis activation of fibrinolysis 67. In aleukemic type of leukemias : amount of leukocytes increases in blood more than 10×109/l amount of leukocytes increases in blood more than 100×109/l amount of leukocytes decreases in blood normal count of leukocytes in blood 68. The cause of the coagulation disorder with disturbance of the 3ed stage of blood coagulation are: hemorrhagic newborn disease lack of kininogen idiopathic thrombocytopenic purpura lack of fibrinogen 69. Reticulocytes are stained with: brilliant cresyl blue sudan black warthin starry hemotoxylin-eosin stain70. Compensatory mechanism of 3 stage of acute post-hemorrhagic anemia is redistribution of blood vasospasm hemodilution tachycardia stimulation of erythropoiesis71. Chronic leukemias are characterized by : . more than 10% of blast cells in the bone marrow immune destruction of leukemic cells in the bone less than 10% of blast cells in the bone marrow heatus leukemicus72. Leukopenia may be a result of : deficit of iron bacterial infection viral infection activation of leukocyte production73. Microcytic hypochromic anemia is seen in: hereditary spherocytosis thalassemia major iron deficiency anemia pernicious anemia74. What kind of changes occurs in peripheral blood during chronic myeloid leukemia? the absence of hiatus leukemicus the presence of hiatus leukemicus increase of blast count in peripheral blood blasts cells more than 90%75. The count of platelets lead to hemorrhagic syndrome: is less than 150 х 109 /l is less than 320 х 109 /l is less than 50 х 109 /l is less than 400 х 109 /l 76. What changes occur in peripheral blood at acute lymphoblastic leukemia? small count of lymphoblasts increased count of megaloblasts a lot of lymphoblasts the presence of Botkin-Gumbrecht bodies 77. Inducers of platelets aggregation are: aspirin ATP urea thrombin 78. Earliest feature of correction of iron deficiency anemia is: increase in serum ferritin reticulocytosis increase in RBC count increase in serum iron level immediately79. The nuclear shift to the left (regenerative) is: decrease the mature leucocytes from common count of leucocytes increase the count of immature neutrophils increase percent of the lymphocytes decrease the count of granular leukocytes 80. What is leukemia? sign of viral infection sign of the inflammation tumor of hematopoietic tissue sign of the allergy 81. Index of the nuclear shift is relation: of the count of immature forms of neutrophils to mature ones: of granulocytes and nongranilocytes of the count of granulocytes to band forms of the myeloblasts to myelocytes 82. What is the cause of hemorrhagic syndrome during leukemia? increased release of intrinsic procoagulants infiltration of the vascular wall by leukemic cells severe anemia severe thrombocytopenia 83. Chronic hypoxia leads to: olygocythemic hypovolemia polycythemic hypovolemia polycythemic normovolemia84. The factor which converts the prothrombin to thrombin : factor I factor VII factor IХа factor Ха 85. Mechanisms of leukopenia are : suppression of leukopoiesis decreased margination of leukocytes in the vascular bed decreased extravasation of leukocytes into tissues decreased leukocyte destruction by the spleen 86. The components of anticoagulation system are: antithrombin III angiotensin adrenaline antihemophylic globulin 87. Dehydration leads to: olygocythemic hypovolemia polycythemic hypovolemia olygocythemic normovolemia88. Fibrinolytics – are: antithrombin III antihemophylic globulin heparin plasmin 89. Lack of vitamin K leads to: coagulation disorder disseminated intravascular coagulation (DIC) syndrome thrombocytopenia angiopathia 90. Which factor can initiate blood coagulation? factor I factor Х factor ХII prothrombin 91. The platelet-vascular hemostasis is necessary for: white trombus formation red thrombus formation the postcoagulative changing of the thrombus vasoconstriction92. Substances can split the fibrin molecule? plasmin heparin-like molecule antithrombin III protein C 93. Signs of degenerative shift to the left are all listed, except: decrease of the total number of segmented neutrophils presence of myelocytes, young neutrophils increase of the nuclear index increase of the number of stab neutrophils94. One of the developmental stages of neutrophylic leukocyte is : myeloblast prolymphocyte promonocyte monoblast 95. Acute purulent inflammatory processes lead to : eosinophilia lymphocytosis neutrophilic leukocytosis basophilia96. What kind of cells in the peripheral blood indicates acute myeloid leukemia? myelocytes immature lymphocytes myeloblasts lymphocytes 97. Coagulation disorders are: scorbut Henoch-Schonlein purpura idiopapthic thrombocytopenic purpura hemophilia 98. The cause of the coagulation disorders with disturbance of the first phase of blood coagulation is the deficiency of: vitamin K Hageman’s factor fibrinogen plasmin 99. The synthesis of thrombin is blocked by calcium ions collagen von Willebrand factor anticoagulants 100. DIC may be caused by: prolonged pregnancy fat embolism amniotic fluid embolism minor injuries101. What concerns to hemorrhagic hemostasiopathias disseminated intravascular coagulation – DIC thrombosis angiopathias thrombocytosis102. Vitamin B12 deficiency results in: macrocytic anemia iron deficiency anemia anemia of chronic diseases aplastic anemia103. The coagulation disorders are: Henoch-Schonlein purpura idiopathic thrombocytopenic purpura hemophilia scorbut 104. Thrombogenic property of the endothelium is caused by production of: prostacyclin protein C NO angiotensin II 105. RBC contains? iron folic acid vitamin C biotin106. Increased osmotic fragility is characteristic of: hereditary microspherocytosis sickle cell anemia thalassemia iron deficiency anemia107. One of the developmental stages of lymphocyte is: myeloblast lymphoblast promonocyte monoblast 108. What are the main changes in the hemogram during acute leukemia? low percent of the blasts the presence of the cells of 5 class of maturation the presence of hiatus leukemicus monocytosis109. Leukemoid reaction is characterized by: leukopenia leukocytosis amount of blasts more than 30% hiatus leukemicus 110. Signs of a regenerative shift to the left are all listed, except: increase in the total number of segmented neutrophils presence of myelocytes, metamyelocytes increase of the nuclear index decrease of the nuclear index111. The endothelial cells of intact vessels prevent blood coagulation by secretion of: prostacyclin thromboxane factor IX vitamin К 112. The causes of hemorrhagic angiopathias – are: allergy diabetes insipidus hypovitaminosis Р and С thrombocytopenia113. Increased count of eosinophils and basophils can be observed at: chronic lymphoid leukemia chronic myeloid leukemia acute lymphoblastic leukemia acute myeloblastic leukemia 114. Anticoagulant system is aimed at: depression of blood coagulation thrombolysis formation of clots activation of blood coagulation115. Compensatory mechanism of 2 stage of acute post-hemorrhagic anemia is: redistribution of blood vasospasm hemodilution tachycardia116. Nuclear shift shows : type of leukocytosis severity of inflammation type of leukopenia stage of inflammation 117. Iron deficiency anemia is seen with all of the following, except: chronic blood loss achlorhydria extensive surgical removal of the proximal small bowel excess of meat in the diet118. What type of leukocytes increases in viral infection? eosinophils neutrophils monocytes lymphocytes 119. What leukocytes present in the peripheral blood of healthy people? myeloblasts promyelocytes lymphoblasts lymphocytes 120. Percentage of blasts in acute myeloid leukemia: 8% 15% more than 20%121. What diseases are often accompanied with monocytosis? tuberculosis helminthic invasion asthma bacterial pneumonia 122. GLUT present on surface of RBC? GLUT 1 GLUT 2 GLUT 3 GLUT 4123. Morphologically recognized granulocytic cell is: lymphoblast myeloblast monoblast erythroblast 124. Components of anticoagulant system are: antithrombin III antihemophylic globulin angiotensin adrenaline125. Endoerythrocytic hemolytic anemias are: membranopathy hemoglobinopathy enzymopathy vasculopathy126. Chronic myeloid leukemia is characterized by: eosinophilic-basophilic association . hiatus leukemicus more than 30% of the blast cells in the peripheral blood lymphocytosis127. Hemosthasiopathias – are the disturbances of : hemostasis system homeostasis red blood cells white blood cells 128. The major constituent of white thrombus is: fibrin RBC WBC platelets 129. Lack of calcium leads to: increased hemorrage thrombosis disseminated intravascular coagulation (DIC) syndrome excess of thrombus retraction 130. Idiopathic thrombocytopenic purpura is example of a : coagulation disorder thrombocytopenia angiopathy thrombophilia 131. What disease can lead to eosinophilia? croupous pneumonia 2. tuberculosis helminthic invasion cardiac infarction 132. Normal value of color index is: 0.85-1.0 0.5-0.8 0.1-1.0 0.1-0.8133. The main sign of hemorragic hemostasiopathia is: increased coagulability of blood increased bleeding increased thrombocytopoiesis 134. Chronic lymphoid leukemia is characterized by: increased number of lymphoblasts more than 60% the presence of the toxic granules in myeloid cells lymphocytosis neutrophilic leukocytosis Loading …Is fire hot or cold?